Post Doctoral Associate ,University of Georgia
Central Drug Research Institute, India
Dissertation Title: “Investigation of New Heterocycles: Synthesis and Biological Activity” Thesis Advisor: Dr. K. Hajela
► M.Sc. Organic Chemistry (2001-2003)
Lucknow University, India
► B.Sc. (Chemistry, Botany, Zoology) 1996-1999
Expertise in various disciplines of organic chemistry.
Demonstrated ability to work, plan, organise and implement projects.
Noted for strong practical and communicational skills.
Can work well in a collaborative environment.
► Qualified NET (CSIR) Test conducted by Council for Scientific and Industrial Research (2004 and in 2005).
► Qualified for CDRI, Ph.D programme entrance test .
► Institute fellowship of Ministry of Health (MOH) in CDRI (2003-2006), Lucknow, India. .
► Post- Doctoral Associate (2009 to till date) in Drug Discovery group in College of Pharmacy, University of Georgia (USA) since (work involve design and synthesis of antiviral nucleosides & Nucleotides, Pro-drug synthesis).
► Research Scientist (Feb 2008 – June 2009) in Jubilant Chemsys Research Foundation, Noida, India. (work involved multiple step synthesis of various biologically active molecules).
► Chemistry Faculty (2007-2008) in NARAYANA GROUP OF EDUCATION .
► Graduate Researcher (Ph.D) [Sept 2003 – Feb 2008] under the guidance of Dr. K. Hajela Central Drug Research Institute, India .
► Research Work In Ph.D. .
1. Synthesis of tetracyclic Benzofuran derivatives as Selective Estrogen Receptor Modulators (SERMs) .
2. Synthesis of tetrazolyl Indole derivatives as Post- Coital Contraceptive agents. Analysis of compounds by X-ray chromatography.
3. Synthesis of coumarin and 2,2-Dimethyl-2H-chromen derivatives as anti-bone resorptives .
4. Synthesis and Biological evaluation of novel series of Bisphosphonates with antiostioporotic activity on bone in vitro.
5. Synthesis of oxadiazolyl Indole derivatives as potent antimicrobial and antimycobacterial agents .
6. Synthesis of New Hydrazone derivatives of Tetracyclic Indole as potent antimicrobial agent.
7. Synthesis, antimicrobial and antimalarial activities of new Thiosemicarbazones/ Isothiosemicarbazone derivatives. .
► Contribute to drug design and discovery.
► Synthesis of heterocyclic compounds of pharmacological interest.
► Synthesis of Chiral Auxillaries used for carrying out Asymmetric Synthesis.
► Synthesis of bioactive natural products and their isosters.
► To fill the gap between basic chemistry and applied chemistry..
► “Synthesis of Entecavir and its Novel Class of Analogues.” Ravindra K. Rawal, Uma Sharan Singh, Srinivas Gadthula and Chung K. Chu. Current Protocols in Nucleic Acid Chemistry 2011 (Accepted).
► “Synthesis and Antiviral Activity of (+)-9-[(1R,2R,3R,4R)-2-Fluoro-3-hydroxy-4-(hydroxymethyl)-5-methylenecyclopentan-1-yl]adenine Against Wild-type and Drug-resistant Hepatitis B Virus (HBV) Mutants.” Jianing Wang, Uma S. Singh, Jakyung Yoo, Dong Woo, Jae-Eun Joo, Ravindra K. Rawal, Zhuhui Huang, Michael G. Murray, Brent Korba and Chung K. Chu. ACS Med. Chem. Lett. (2010 Revision submitted).
► “A facile one pot synthesis of 4-aroyl-2-pyrones: via nuclliophillic addition of active methylene groups to 1, 2-diaroylacetylenes” Ravi Shankar, Uma Sharan Singh, Harsha Shukla, Vinay Thakur and K. Hajela Synthetic Commu. 2010 (Accepted).
► “Synthesis and Biological Evaluation of 3,4,6-Triaryl-2-Pyranones as a Potential New Class of Anti-breast Cancer Agents.” Ravi Shankar, Bandana Chakravarti, Uma Sharan Singh, Shailendra Kumar Dhar Dwivedi, Hemant Kumar Bid, Rituraj Konwar, Geetika Kharkwal,Vishal Chandra, Anila Dwivedi & K. Hajela Bioorganic & Medicinal Chemistry 2009, 17 (11), 3847-3856.
► “Synthesis and Biological Evalution of Indolyl Bispohosphonates as Anti-bone resorptive and Anti-leishmanial agents.” Uma Sharan Singh , Ravi Shankar, Avinash Kumar, Ritu Trivedi, Naibedya Chattopadhyay, Nishi Shakya, Shraddha Palne, Suman Gupta & K Hajela. Bioorganic Medicinal Chemistry 2008, 16, 8482-8491.
► “Synthesis and Structure Guided Evaluation of Estrogen Agonist and Antagonist Activities of Some New Teterazolyl Indole Derivatives.” Uma Sharan Singh, Ravi Shankar, M.M. Singh, Govind Keshri, Gaya P. Yadav, P.R. Moulik and K. Hajela. European Journal of Medicinal Chemistry 2007, 17, 18155810 (P,S,E,B,D).
► “An efficient and improved synthesis of 1,5-diketones : versatile conjugate addition of nucleophiles to α , β-unsaturated enones and alkynones”. Ravi Shankar, Ashok K. Jha, Uma Sharan Singh and K. Hajela. Tetrahedron Lett., 2006, 47, 3077-3079.
► A Novel Anti-HBV Carbocyclic Nucleoside Active Against Wild-type and Drug-Resistant Hepatitis B Virus (HBV) Mutants. J. Wang, U.S.Singh, J. Yoo, J.E.Joo, Z.Huang, M. Murray, B. Korba and C.K. Chu. International Round Table on Nucleosides, nucleotides and Nucleic Acids, 2010, pp 148-149. IRT, Lyon 29th Augest-3rd Sept 2010.
► Synthesis and Post-Coital Contraceptive of some Tetrazolyl Indole Derivative. Uma Sharan Singh, Ravi Shankar, M.M. Singh, Govind Keshri, Gaya P. Yadav, P.R. Moulik and K. Hajela. Med. Chem. Res. 2007, 15, 306-307. Current Trends in Drug Discovery Research, Central Drug Research Institute Lucknow India, 17-21 Feb-2007.
► Synthesis of Some Novel Conformationally Constrained Tricyclic Compounds as Potential Estrogen Receptor Agonists/Antagnists. Ravi Shankar, Ashok K. Jha, Uma Sharan Singh, Govind Keshri, Anila Dwivedi, Anil. K. Balapure, M.M. Singh and K. Hajela.SERMs as Major Therapeutic Advance Towards Multifunctional Medicines For Clinical Practice. K. Hajela, Ashok K. Jha, and Uma Sharan Singh. Med. Chem. Res. 2003, 12, 290.Current Trends in Drug Discovery Research, Central Drug Research Institute Lucknow India, 17-21 Feb-2007.
► SERMs as Major Therapeutic Advance Towards Multifunctional Medicines For Clinical Practice. K. Hajela, Ashok K. Jha, and Uma Sharan Singh. Med. Chem. Res. 2003, 12, 290. Current Trends in Drug Discovery Research, Central Drug Research Institute Lucknow India, 17-21 Feb-2004.
► Synthesis of Tetracyclic Benzo[b] Naphtho [2,3-d] Furans/Thiophene as Possible Selective Receptor Modulators (SERMs). Ashok K. Jha, P. C. Sharma, U. S. Singh, K. Hajela, M. M. Singh, A. K. Balapure. Med. Chem. Res. 2003, 12, 256. Current Trends in Drug Discovery Research, Central Drug Research Institute Lucknow India, 17-21 Feb-2004 .
374 College of Pharmacy
Uviversity of Georgia
Athens, Georgia 30602-2352 (USA)
E-mail: ussinghcdri@gmail.com
Tel : +(1)706-542-5395 (off.)